Endocrine Abstracts

Hypertension or elevated arterial blood pressure (BP) is the most common cause of cardiovascular diseases (CVDs). The arterial BP is regulated by renin-angiotensin-aldosterone system (RAAS), whereas dysfunctional RAAS may lead to development of hypertension and associated CVDs. Parathyroid hormone (PTH) secreted by parathyroid glands regulates RAAS by directly stimulating aldosterone synthesis in zona glomerulosa cells, which leads to development of hypertension. Conversely, R...

Diabetes mellitus type-II (DM-2) is a metabolic disorder characterized by high blood glucose levels due to insulin resistance and relative insulin deficiency. DM-2 often leads to hypertension, a prolonged condition of elevated blood pressure (BP). Both hypertension and diabetes have a pathological role in causing cardiovascular diseases (CVDs). While renin-angiotensin-aldosterone system (RAAS) regulates arterial BP, any pathology in RAAS system may lead to hypertension and rel...